|September 5, 2014||
WEBINAR: Progesterone Treatment of Menopausal Hot Flashes and Sleep Disturbances – by Jerilynn Prior MD
Progesterone Treatment of Menopausal Hot Flashes and Sleep Disturbances – by Jerilynn Prior MD
Wednesday September 10, 2014 – 8:30pm – 10pm ET (5:30 PT)
The conventional etiological concept of hot flush/flash and night sweat (Vasomotor Symptom, VMS) experiences is estrogen deficiency. A Cochrane meta-analysis also makes it clear that conventional estrogen or estrogen-progestin therapies are very effective for VMS. However, even if estradiol or estradiol/progesterone are used there remain disadvantages and risks (no VMS-independent improvements in sleep, potential vascular diseases, breast cancer) and not all women are willing to take estrogen/estradiol.
This presentation will show you RCT evidence that oral micronized progesterone (Progesterone, alone, without estradiol) significantly improves troublesome as well as severe (FDA definition of >7 mod-very intense VMS/week) hot flushes/flashes in healthy women 1-10 years from their last flow. In addition it will review the evidence that OMP improves sleep and is safe for the cardiovascular system and breast health risks in older women and will increase bone formation.
- Do menopausal women who refuse or shouldn’t take estradiol-based therapies have effective options for severe hot flushes?
- Does stopping progesterone cause a rebound increase in hot flushes (as often occurs when stopping estradiol)?
- Is Oral Micronized Progesterone in luteal phase doses safe in terms of bone, heart and breast health?
Jerilynn C. Prior MD, FRCPC, ABIM, ABEM, is a professor of endocrinology and metabolism at the University of British Columbia, and a pioneer in research involving women’s menstrual cycles and ovulation, perimenopausal endocrinology and treatment and progesterone and bone physiology. She is known for research showing that cyclic progesterone is effective treatment of abnormal menstrual cycles in younger, normal-weight women with hypothalamic suppression. She is also known for researching the endocrinology and treatment of hot flushes/flashes and night sweats in both peri- and menopausal women. She believes that silent ovulatory disturbances (anovulation and short luteal phases) within normal-length cycles are a major, unrecognized risk for subsequent osteoporosis, heart attacks and breast cancer. She is also the founder and Scientific Director of the Centre for Menstrual Cycle and Ovulation Research (CeMCOR,www.cemcor.ubc.ca) whose goals are to perform innovative research and to make new research results freely available to health care providers and to women.