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Systems Biology

Systems Biology, Functional Medicine, and Folates

Jeffrey Bland, PhD, FACN, FACB

Abstract
Human biology is often not as simple as it seems on the surface. This is certainly the case with folates and their relationship to disease prevention. During the decades from the 1960s through the 1980s, Smithells made the discovery that folic acid was important in the prevention of neural tube defects in babies,1 Butterworth made the observation that folic acid was important in the prevention of cervical dysplasia,2 and McCully reported that folic acid was an important nutrient for the prevention of atherosclerosis associated with elevated homocysteine.3 These 3 observations redefined the clinical importance read more…

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