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Rheumatoid Arthritis

Slideshow: Integrative Nutritional Approach to the Treatment of Rheumatoid Arthritis

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Slideshow: A Systemaic Review: Antioxidants and anti-inflammatory dietary supplements for osteoarthritis and rheumatoid arthritis

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Differential metabolic effects of glucosamine and Nacetylglucosamine in human articular chondrocytes

Alexander R. Shikhman, Diana C. Brinson, Jean Valbracht and Martin K. Lotz

Abstract
Objective—Aminosugars are commonly used to treat osteoarthritis; however, molecular mechanisms mediating their anti-arthritic activities are still poorly understood. This study analyzes facilitated transport and metabolic effects of glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) in human articular chondrocytes.

Methods—Human articular chondrocytes were isolated from knee cartilage. Facilitated transport of glucose, GlcN and GlcNAc was measured by uptake of [ 3H]2-deoxyglucose, [ 3H]GlcN and [ 3H] GlcNAc. Glucose transporter (GLUT) expression was analyzed by Western blotting. Production of sulfated glycosaminoglycans (SGAG) was measured using [ 35 S]SO4. Hyaluronan read more…

An Integrative Nutritional Approach To The Treatment Of Rheumatoid Arthritis

Dan Lukaczer, ND

Abstract
Rheumatoid arthritis (RA)—a systemic autoimmune disorder characterized by chronic inflammation of the synovial membranes—is associated with considerable financial costs and morbidity. Symptoms of RA generally begin as morning stiffness and pain in the small joints of the hands and feet, sometimes progressing to the larger joints and the cervical spine. read more…

Antioxidants and Anti-inflammatory Dietary Supplements for Osteoarthritis and Rheumatoid Arthritis

Cathy Creger Rosenbaum, PharmD, MBA, RPh; Dónal P. O’Mathúna, PhD; Mary Chavez, PharmD, FAACP; Kelly Shields, PharmD

Objective • To review efficacy studies of antioxidant and anti-inflammatory dietary supplements used to manage osteoarthritis (OA) and rheumatoid arthritis (RA) and make conclusions about their place in therapy. Glucosamine, chondroitin, and methyl sulfonyl methane were excluded.

Data Sources • A literature search was conducted using MEDLINE (1996 through January 2009), EMBASE, Cochrane Library, Natural Medicines Comprehensive Database, and Natural Standard, with bibliographic review of relevant articles. Cited studies from before our search range were included if they represented the only published human read more…

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