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Some Joint Health Supplements Mislabeled:

Glucosamine, chondroitin, Boswellia and MSM are popular dietary supplement ingredients for treating symptoms of osteoarthritis—worn joint cartilage. But some products don’t contain listed ingredients, are contaminated with lead, or do not break apart properly, according recent analyses by, White Plains, NY.

In fact, 3 of 18 supplements (17%) for people selected for review failed testing, as did all four of the products for dogs and cats. Additional products that passed testing, including two for pets, were identified through’s Quality Certification Program.

Twenty-nine percent of people who take multiple dietary supplements take a joint health supplement according to read more…

Differential metabolic effects of glucosamine and Nacetylglucosamine in human articular chondrocytes

Alexander R. Shikhman, Diana C. Brinson, Jean Valbracht and Martin K. Lotz

Objective—Aminosugars are commonly used to treat osteoarthritis; however, molecular mechanisms mediating their anti-arthritic activities are still poorly understood. This study analyzes facilitated transport and metabolic effects of glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) in human articular chondrocytes.

Methods—Human articular chondrocytes were isolated from knee cartilage. Facilitated transport of glucose, GlcN and GlcNAc was measured by uptake of [ 3H]2-deoxyglucose, [ 3H]GlcN and [ 3H] GlcNAc. Glucose transporter (GLUT) expression was analyzed by Western blotting. Production of sulfated glycosaminoglycans (SGAG) was measured using [ 35 S]SO4. Hyaluronan read more…

Efficacy, Tolerability, and Safety of a Multicomponent Antiinflammatory With Glucosamine Hydrochloride vs Glucosamine Sulfate vs an NSAID in the Treatment of Knee Osteoarthritis—A Randomized, Prospective, Double-Blind, Comparative Study

J. Nandhakumar, MPharm; S. Sengottuvelu, MPharm, PhD; Manoj G. Tyagi, MSc, PhD; P.P. Sethumathi, MSc, MPhil;
D. Karthikeyan, MPharm, PhD; M. Vasudevan, MPharm, PhD; S. Narmadha, MPharm, PhD; and T. Sivakumar, MPharm, PhD

Purpose: Our purpose in this study was to compare the efficacy, tolerability, and safety of a multicomponent antiinflammatory preparation containing glucosamine hydrochloride (g hydrochloride) or plain glucosamine sulfate (g sulfate) with that of a nonsteroidal antiinflammatory drug (NSAID), aceclofenac, in the treatment of knee osteoarthritis.

Methods: Forty-five patients with active osteoarthritis of the knee joint were randomized to receive g hydrochloride, g sulfate, or aceclofenac for 12 read more…

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