Neuro Endo Immune Learning Center
By David Marc, B.S. and Kelly Olson, Ph.D.
Originally published in NeuroScience Inc.
The purpose of this overview is to identify neurological and immunological abnormalities that exist in individuals with autism and discuss neuroimmune biomarker testing for autism, which can identify abnormalities and ensure therapeutic effectiveness. read more…
Jeannemarie M. Beiseigel, PhD, RD and Deanna J. Fall, BAa
Age-related cognitive decline adversely affects a significant portion of the population. Studies have suggested that cognition may be maintained by supporting cholinergic function and overall brain health. Zymenta and Cerelist are nutritional supplements that address nutritional deficiencies that may be related to mild cognitive decline by providing complementary ingredients to 1) support acetylcholine (Ach) synthesis; 2) reduce ACh breakdown; and 3) protect neuronal cell structure and function. This article reviews the health implications of a cholinergic deficit in patients with cognitive complaints and describes how the ingredients in Zymenta read more…
aa David Marc, B.Sc. , & Kelly Olson Ph.D .
Autism is a developmental disorder characterized by immunological and neurological abnormalities. The role of cytokines in the pathophysiology of autism has been researched suggesting a relationship with altered blood-brain barrier permeability and subsequent neuroinflammation. Cytokine recruitment to the CNS may result in altered neurotransmitter signaling and the behavioral manifestation of autism symptoms. Other immune mediated events such as changes in the number and activity of natural killer cells, macrophages, immunoglobulins, and glutathione may contribute to altered neuronal signaling and neurotransmitter imbalances. The purpose of this overview is to examine read more…
DeannaJ.Fall,BAa,b and Sirid-AiméeKellermann,PhD
Methylation, the addition of a methyl group to facilitate a biochemical reaction, is vital to a wide variety of biological processes. Among other things, methylation facilitates detoxification (especially in the liver), and is important for proper functioning of the hypothalamic-pituitary-adrenal (HPA) axis. It is critical for the synthesis of all monoamine neurotransmitters and histamine; for example, the enzyme that converts norepinephrine to epinephrine is dependent on methylation for activation.
A variety of extrinsic and intrinsic factors including stress, nutritional deficits, certain disease states, and genetics can contribute to insufficient methylation. This can result in a reduced read more…
Chenggang Jin, PhD, MDa,b, Deanna J. Fall, BAc, Diana Roen BS,a and Gottfried Kellermann, PhDc
Lyme disease is the most reported vectorborne illness in the United States. The incidence may be vastly under-reported due to limitations of current testing methodologies; the need for more sensitive and specific tests is apparent. The iSpot LymeTM assay is a new generation of in vitro diagnostic test for the detection of antigen-specific effector/memory T cells that respond to stimulation by Borrelia burgdorferi antigens. The highly sensitive T cell-based enzyme-linked immunospot (ELISPOT) methodology enumerates the Borrelia burgdorferi activated effector/memory T cells. This assay is read more…