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Neuro Endo Immune Learning Center

Slide Show Neuroimmunology of Autism Spectrum Disorder

By David Marc, B.S. and Kelly Olson, Ph.D.
Originally published in NeuroScience Inc.

The purpose of this overview is to identify neurological and immunological abnormalities that exist in individuals with autism and discuss neuroimmune biomarker testing for autism, which can identify abnormalities and ensure therapeutic effectiveness. read more…

Zymenta and Cerelist: A novel approach to nutritional management of cholinergic deficiency

Jeannemarie M. Beiseigel, PhD, RD and Deanna J. Fall, BAa

Age-related cognitive decline adversely affects a significant portion of the population. Studies have suggested that cognition may be maintained by supporting cholinergic function and overall brain health. Zymenta and Cerelist are nutritional supplements that address nutritional deficiencies that may be related to mild cognitive decline by providing complementary ingredients to 1) support acetylcholine (Ach) synthesis; 2) reduce ACh breakdown; and 3) protect neuronal cell structure and function. This article reviews the health implications of a cholinergic deficit in patients with cognitive complaints and describes how the ingredients in Zymenta read more…

Neuroimmunology of Autism Spectrum Disorder

aa David Marc, B.Sc. , & Kelly Olson Ph.D .

Autism is a developmental disorder characterized by immunological and neurological abnormalities. The role of cytokines in the pathophysiology of autism has been researched suggesting a relationship with altered blood-brain barrier permeability and subsequent neuroinflammation. Cytokine recruitment to the CNS may result in altered neurotransmitter signaling and the behavioral manifestation of autism symptoms. Other immune mediated events such as changes in the number and activity of natural killer cells, macrophages, immunoglobulins, and glutathione may contribute to altered neuronal signaling and neurotransmitter imbalances. The purpose of this overview is to examine read more…

Methylation: Fundamental to a Healthy Nervous System

DeannaJ.Fall,BAa,b and Sirid-AiméeKellermann,PhD

Methylation, the addition of a methyl group to facilitate a biochemical reaction, is vital to a wide variety of biological processes. Among other things, methylation facilitates detoxification (especially in the liver), and is important for proper functioning of the hypothalamic-pituitary-adrenal (HPA) axis. It is critical for the synthesis of all monoamine neurotransmitters and histamine; for example, the enzyme that converts norepinephrine to epinephrine is dependent on methylation for activation.

A variety of extrinsic and intrinsic factors including stress, nutritional deficits, certain disease states, and genetics can contribute to insufficient methylation. This can result in a reduced read more…

iSpot LymeTM: A New Generation of Lyme Disease Testing

Chenggang Jin, PhD, MDa,b, Deanna J. Fall, BAc, Diana Roen BS,a and Gottfried Kellermann, PhDc

Lyme disease is the most reported vectorborne illness in the United States. The incidence may be vastly under-reported due to limitations of current testing methodologies; the need for more sensitive and specific tests is apparent. The iSpot LymeTM assay is a new generation of in vitro diagnostic test for the detection of antigen-specific effector/memory T cells that respond to stimulation by Borrelia burgdorferi antigens. The highly sensitive T cell-based enzyme-linked immunospot (ELISPOT) methodology enumerates the Borrelia burgdorferi activated effector/memory T cells. This assay is read more…

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