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GERD

Improvement Of Gastroesophageal Reflux Disease After Initiation Of A Low-Carbohydrate Diet: Five Brief Case Reports

William S. Yancy, Jr, MD, MHS, Dawn Provenzale, MD, MSPH, and Eric C. Westman, MD, MHS

Abstract
Heartburn (pyrosis) and gastroesophageal reflux symptoms are common complaints encoun- tered in outpatient medical clinics.1 It is esti- mated that up to 40% of adults in the United States have occasional heartburn (approximate- ly once a month) and up to 10% experience daily heartburn.2,3 In addition, these symptoms have a substantial effect on health-related quality of life (QOL); in some studies, QOL can be impaired as severely as with angina or heart failure.4 Medications used to treat these symptoms have been among the read more…

Melatonin for the Treatment of Gastroesophageal Reflux Disease: A Case Report

Melvyn R. Werbach, MD

Abstract
The enterochromaffin cells of the gastrointestinal (GI) tract secrete 400 times as much melatonin as the pineal gland; therefore, it is not surprising that research is finding that this indole plays an important role in GI functioning. In animal studies, it protects against GI ulcerations, and randomized clinical trials suggest its efficacy in treating functional dyspepsia and irritable bowel syndrome. Melatonin administration has been shown to protect against esophageal lesions in animals. Moreover, in a randomized, single-blind clinical trial of subjects with gastroesophageal reflux disease (GERD), the combination of melatonin with other natural supplements was read more…

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