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Dr Kellermann PhD

iSpot LymeTM: A New Generation of Lyme Disease Testing

Chenggang Jin, PhD, MDa,b, Deanna J. Fall, BAc, Diana Roen BS,a and Gottfried Kellermann, PhDc

Lyme disease is the most reported vectorborne illness in the United States. The incidence may be vastly under-reported due to limitations of current testing methodologies; the need for more sensitive and specific tests is apparent. The iSpot LymeTM assay is a new generation of in vitro diagnostic test for the detection of antigen-specific effector/memory T cells that respond to stimulation by Borrelia burgdorferi antigens. The highly sensitive T cell-based enzyme-linked immunospot (ELISPOT) methodology enumerates the Borrelia burgdorferi activated effector/memory T cells. This assay is read more…

The Hypothalamic-Pituitary-Adrenal Axis: The Actions of the Central Nervous System and Potential Biomarkers

Kelly L. Olson, Ph.D.;David T. Marc, M.S.; Lindsay A. Grude, B.S.; Corena J. McManus, M.S.; Gottfried H. Kellermann, Ph.D.

The adrenal glands are part of an adaptive system involved in the maintenance of a homeostatic biological balance in response to stress. The adrenal glands release cortisol, epinephrine, and norepinephrine to preserve a healthy, but dynamic equilibrium. Specific brain nuclei control adrenal gland function either through the actions of the hypothalamic-pituitary-adrenal (HPA) axis, initiated by traditional HPA drivers like corticotrophin releasing factor (CRF) from the hypothalamus, or through direct innervation by stimulated preganglionic sympathetic nerves. These pathways can be activated read more…

Evaluation of a Novel Elisa for Serotonin: Urinary Serotonin as a Potential Biomarker for Depression

Mikaela I. Nichkova & Han Huisman & Paul M. Wynveen & David T. Marc & Kelly L. Olson & Gottfried H. Kellermann

Depression is a common disorder with physical and psychological manifestations often associated with low serotonin. Since noninvasive diagnostic tools for depression are sparse, we evaluated the clinical utility of a novel ELISA for the measurement of serotonin in urine from depressed subjects and from subjects under antidepressant therapy. We developed a competitive ELISA for direct measurement of serotonin in derivatized urine samples. Assay performance was evaluated and applied to clinical samples. The analytical range of the assay read more…

A Novel Top-down Strategy For Addressing Autonomic Imbalances

Deanna Fall,BA; Bradley Bush,ND and Sirid Kellermann,PhD

All involuntary bodily functions are controlled by the autonomic nervous system (ANS). Because of its extensive influence, when the ANS is out of balance, it can cause a range of health issues involving sleep quality, energy levels, metabolism, gastrointestinal and cardiovascular function, and more. ANS imbalances manifest differently with each patient due to genetic predisposition and numerous other factors. Strides in the elucidation of neurocircuitry have demonstrated that neurotransmitter-based activity in certain regions of the brain directly and indirectly influence ANS function. This paper discusses the relevant neurocircuitry and clinical support for read more…

Addressing Adrenal Imbalance: The Future of Adrenal Health

Deanna J. Fall,BA, and Sirid-Aimée Kellermann,PhD

Poor adrenal function and impairments in the hypothalamic-pituitary-adrenal (HPA) axis can have profound effects on overall health and quality of life. NeuroScience, Inc. has developed a suite of products specifically formulated to support healthy adrenal function for patients experiencing persistent stress. Complementing the current line of adrenal supporting products (AdreCor and Calm-PRT), three new products have been formulated to influence cortisol levels and to support methylation pathways. Here, we summarize the biochemical imbalances that characterize the various stages of adrenal fatigue and discuss interventions specifically designed to address each stage. read more…

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