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Dr Alexander Shikhman

Differential metabolic effects of glucosamine and Nacetylglucosamine in human articular chondrocytes

Alexander R. Shikhman, Diana C. Brinson, Jean Valbracht and Martin K. Lotz

Objective—Aminosugars are commonly used to treat osteoarthritis; however, molecular mechanisms mediating their anti-arthritic activities are still poorly understood. This study analyzes facilitated transport and metabolic effects of glucosamine (GlcN) and N-acetylglucosamine (GlcNAc) in human articular chondrocytes.

Methods—Human articular chondrocytes were isolated from knee cartilage. Facilitated transport of glucose, GlcN and GlcNAc was measured by uptake of [ 3H]2-deoxyglucose, [ 3H]GlcN and [ 3H] GlcNAc. Glucose transporter (GLUT) expression was analyzed by Western blotting. Production of sulfated glycosaminoglycans (SGAG) was measured using [ 35 S]SO4. Hyaluronan read more…

Autoimmune Connection

Is there a connection between celiac disease and other autoimmune disorders? The summer Delight met with Dr. Alexander Shikhmanh, CEO and Founder of the Institute for Specialized Medicine, a state of the art integrative care center for autoimmune disease and arthritis treatment to learn more about this important topic.

Interview with Alexander Shikhman read more…

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