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Compounding Pharmacy

Why Compounded Prescriptions Make Sense: An Interview With David Brownstein, MD

Interview by Kimberly Lord Stewart

David Brownstein, MD, is a family physician and practitioner of holistic medicine. He is the medical director of the Center for Holistic Medicine in West Bloomfield, Mich, and has lectured internationally to physicians and others about his success in using natural hormones and nutritional therapies in his practice. Brownstein specializes in the therapeutic application of vitamins, minerals, herbs, and natural hormones. He is the author of 6 books: Overcoming Arthritis; The Miracle of Natural Hormones; Overcoming Thyroid Disorders; Iodine: Why You Need It, Why You Can’t Live Without It; Salt: Your Way to Health; read more…

Compounding Basics

William Benda, MD

Editor’s Note: This Special Report provides an overview of some of the complex issues involved in compounding pharmacy. There are many benefits to compounding as well as some concerns for safety and quality. We at the journal hope you find these articles helpful as well as insightful and thought provoking.

Drug compounding is a process by which a pharmacist or doctor combines, mixes, or alters ingredients to create a medication tailored to the needs of an individual patient.

Until the advent of drug manufacturing in the 1950s, compounding was the exclusive method of preparing medications for read more…

Giving Menopause Its Proper Place

Bethany Hayes, MD

For the last 50 years, medicine has treated an increasing number of postmenopausal women with hormone replacement therapy (HRT). The accepted thinking was that women who took HRT were healthier than those who did not. Then came the Women’s Health Initiative, a large, well-designed study sponsored by the National Institutes of Health1 while it was under the direction of Bernadine Healy, MD, the first woman to head that organization. When the study was stopped in midstream for safety issues in July 2002, its findings literally turned women’s health on end.

It appeared that HRT offered no read more…

Alternatives to Hormone Replacement for Menopause

Virginia M Soffa, MEd

This paper examines the controversy over estrogen therapies and shows how lifestyle interventions can be offered as a safe way to promote prevention and good health, without the risks and long-term side effects associated with hormone replacement drugs.

Some researchers show that estrogen therapy may decrease osteoporosis and heart disease. Preventing these diseases has become the primary justification for recommending hormones to most menopausal women, whether the loss of estrogen is induced by surgical removal of the ovaries, hysterectomy, ovary radiation, chemotherapy, or is a result of the natural aging process. Prevention is the foremost read more…

Compounded Dispersion Formulations, Part II

Amir H. Shojael, Pharm D, PhD

Summary Review of Part I
When one considers that most compounded prescriptions are forms of dispersed systems, it becomes imperative to grasp a thorough understanding of the theory and technology behind pharmaceutical dispersions. Part I of this article described dispersed systems and the effects of improper compounding of dispersions on the bioavailability and stability of products.

Coarse Dispersions
Based on the particle-sized classification, coarse dispersions have mean particle diameters of greater than 100 nm. Most pharmaceutical suspensions and emulsions are coarse dispersions.

As defined by the [US Pharmacopeia] USP, “suspensions are liquid preparations read more…

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