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The Forgotten Therapeutic Applications of Castor Oil

This ancient remedy is explored by Dr Todd Born ND, in terms of its clinical application and the slowly expanding body of published data on its effects on human physiology and biology.

For many centuries folk lore medicine has recommended the use of castor oil, either orally or transdermally for a wide range of complaints.  Naturopaths and other practitioners continue to utilise its therapeutic potential for the management of the health of their clients and patients.

When confronted with the request for topical application by their health care provider many people will baulk and wonder why they should cover parts of their torso with the sticky oil – whilst blandishments may placate many, I felt that a dive into the literature to see what was currently understood about its purported mechanisms of action there were and how we might translate that alongside our therapeutic considerations.

Castor oil has many potential uses but the most common reasons for considering its application are:

  1. Pain
  2. Inflammation
  3. Swelling
  4. Gas and bloating
  5. Constipation
  6. Detoxification
  7. Fibrocystic breasts
  8. Skin tonification

Castor oil is made from the plant Ricinus communis (castor bean).  It has been used since ancient Egyptian times internally as a cathartic (stimulating laxative) and to induce labour.  Topically, it has been used as a wound healer, anti-inflammatory agent, detoxifier, immunomodulator and has been found helpful in gastrointestinal complaints.[1],[2]

The precise mechanisms of action for this remarkable plant have not been fully elucidated.  Most of the traditional uses come from folk medicines and word of mouth in certain traditions around the world. [3],[4],[5]   

What is known is the main component is considered to be ricinoleic acid (RA), which exert analgesic and anti-inflammatory effects.  Pharmacological characterisation has shown similarities between the effects of RA and those of capsaicin, suggesting a potential interaction of this drug on sensory neuropeptide-mediated neurogenic inflammation.[6]  It is thought to be effective in constipation via ricinoleic acid (RA), which constitutes 90% of castor oil, can bind to VR1 receptors and according to the literature acts to reduce straining.[7],[8] 

Members of the vanilloid receptor family (TRPV) are activated by a diverse range of stimuli, including heat, protons, lipids, phorbols, phosphorylation, changes in extracellular osmolarity and/or pressure, and depletion of intracellular Ca2+ stores. However, VR1 remains the only channel activated by vanilloids such as capsaicin.  These channels are excellent molecular candidates to fulfil a range of sensory and/or cellular roles that are well characterized physiologically.  Furthermore, as novel pharmacological targets, the vanilloid receptors have potential for the development of many future disease treatments.[9] 

Leading theory of how it positively affects the immune system is via T-cells in the skin and augmentation of prostaglandins.[10] The T-11 cell increase represents a general boost in the body’s specific defense status.  Lymphocytes actively defend the health of the body by forming antibodies against pathogens and their toxins.  T-cell lymphocytes originate from bone marrow and the thymus gland as small lymphocytes that identify and kill viruses, fungi, bacteria, and cancer cells.  T-11 cell lymphocytes supply a fundamental antibody capability to keep the specific defense system strong.  The skin T-cell theory postulates that the absorption of castor oil into the skin triggers T-Iymphocytes embedded in the skin, causing them to activate a local and/or generalized immune reaction. [11],[12] 

A well written and referenced review by Drs. Kennedy and Keaton, go into further detail in their April 2012 article titled, Evidence for the Topical Application of Castor Oil.[13]  Here they refer to a study in which 17 patients with fatigue were enrolled in a trial and “during the course of treatment, the mean total lymphocyte counts normalised within the group and were lower at the end of treatment vs. baseline.  As an unexpected outcome, 2 participants with elevated liver enzymes and cholesterol levels normalised these variables by the end of the study.” Bit of an NAFLD link here?

It is known that transdermal absorption occurs, given that castor oil is fat soluble, but the exact biochemical pathway is not understood.[14] 

As this review has indicated, castor oil is of potentially high therapeutic value, with low odour, low side effect, low risk profile that is highly underutilised in today’s modern medical world.

Conclusion

The level of evidence for applicability from some of the published basis is weak, but what does exist suggests numerous explanations and extremely low risk to the individual applying the treatment.  I personally have prescribed this to hundreds of patients for all of the reasons discussed in this article and have found profound therapeutic benefit in all capacities.

About Dr. Todd Born

Dr. Todd A. Born is in private practice with his wife, Dr. Lindsay Jones-Born, at Born Naturopathic Associates, Inc., in Alameda, CA (www.bornnaturopathic.com).  He is licensed in California & Connecticut.  He is also Product Manager at Allergy Research Group, LLC and a Thought Leader for UK-based “Clinical Education,” a free peer-to-peer service that offers clinicians a closed forum to ask clinical questions and receive evidence-based responses by experts in their fields.  Dr. Born graduated from Bastyr University in Seattle and completed his residency at the Bastyr Center for Natural Health and its thirteen teaching clinics, with rotations at Seattle-area hospitals.  He may be reached at dr.born@bornnaturopathic.com.


[1] Duke, James A. “Ricinus Communis.” Ricinus Communis L. 9 Jan. 1998. Web. 9 Apr. 2013.  (View Abstract).  All tiny URL links need to be embedded in text View Abstract

[2] Felter, Harvey Wickes. “Oleum Ricini.  Henriette’s Herbal Homepage.” Welcome. Henriette’s Herbal Homepage. 1922. Web. 9 Apr. 2013.  (View Abstract). 

[3] Duke, James A. “Ricinus Communis.” Ricinus Communis L. 9 Jan. 1998. Web. 9 Apr. 2013.  (View Abstract). 

[4] Felter, Harvey Wickes. “Oleum Ricini.  Henriette’s Herbal Homepage.” Welcome. Henriette’s Herbal Homepage. 1922. Web. 9 Apr. 2013.  (View Abstract).  

[5] McGarey, William A. The Oil That Heals: a Physician’s Successes with Castor Oil Treatments. Virginia Beach, VA: A.R.E., 1993

[6] Vieira C, et al.  Effect of ricinoleic acid in acute and subchronic experimental models of inflammation.  Mediators Inflamm. 2000;9(5):223-8.  (View Abstract). 

[7] Arslan GG, Eser I.  An examination of the effect of castor oil packs on constipation in the elderly.  Complement Ther Clin Pract. 2011 Feb;17(1):58-62.  (View Abstract). 

[8] Vieira C, et al.  Pro- and anti-inflammatory actions of ricinoleic acid: similarities and differences with capsaicin.  Naunyn Schmiedebergs Arch Pharmacol. 2001 Aug;364(2):87-95.  (View Abstract). 

[9] Gunthorpe MJ, et al.  The diversity in the vanilloid (TRPV) receptor family of ion channels.  Trends Pharmacol Sci. 2002 Apr;23(4):183-91.  (View Abstract). 

[10] Grady Harvey.  Immunomodulation through castor oil packs.  Journal of Naturopathic Medicine. Unknown; 7(1):84-89.  (View Abstract). 

[11] Schmidt RE, et al.  T11/CD2 activation of cloned human natural killer cells results in increased conjugate formation and exocytosis of cytolytic granules.  J Immunol. 1988 Feb 1;140(3):991-1002.  (View Abstract). 

[12] [12] Grady Harvey.  Immunomodulation through castor oil packs.  Journal of Naturopathic Medicine. Unknown; 7(1):84-89.  (View Abstract).

[13] Kennedy, DA & Keaton D.  Evidence for the Topical Application of Castor Oil.  Int Jrnl Nat Med. Apr 2012;5(1).  (View Abstract). 

[14] Mein E, et al.  Transdermal absorption of castor oil. . Evidence-Based Integrative Medicine 2005; 2: 239-244.  (View Abstract).  

 


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