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Managing Biotransformation: Introduction and Overview

Jeffrey Bland, PhD, FACN

A description of the family of human detoxification enzymes, cytochrome P450s, first appeared in the literature in 1962.1 Until that time it was known that foreign compounds were somehow detoxified by specific physiological processes, but the nature of these processes had not been elucidated. In the absence of an understanding about this superfamily of detoxification enzymes (now known to be generated by 57 genes, many of which show multiple polymorphisms), there was much speculation as to how an individual actually eliminated lipophilic compounds, both exogenous and endogenous. It is now recognized that the enzymes in read more…

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