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Ineffectiveness of Zinc Gluconate Nasal Spray and Zinc Orotate Lozenges in Common-Cold Treatment: A Double-Blind, Placebo-Controlled Clinical Trial

George A. Eby, MS; William W. Halcomb, DO

Zinc gluconate lozenges (23 mg zinc each 2 wakeful hours) were first reported by Eby, Davis, and Halcomb to shorten common colds by 7 days.1 Side effects of zinc gluconate lozenges included unpalatable taste, strong astringent feeling in the mouth (ie,mouth-feel), mouth irritation, and taste distortion. Complaints were attributed to the zinc compound and use of the lozenge method. Other zinc lozenges have since been studied, with lozenge efficacy being found to be directly related to total daily positively charged zinc administered and unrelated to total dosage of zinc.2 However, nasal read more…

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