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Efficacy, Tolerability, and Safety of a Multicomponent Antiinflammatory With Glucosamine Hydrochloride vs Glucosamine Sulfate vs an NSAID in the Treatment of Knee Osteoarthritis—A Randomized, Prospective, Double-Blind, Comparative Study

J. Nandhakumar, MPharm; S. Sengottuvelu, MPharm, PhD; Manoj G. Tyagi, MSc, PhD; P.P. Sethumathi, MSc, MPhil;
D. Karthikeyan, MPharm, PhD; M. Vasudevan, MPharm, PhD; S. Narmadha, MPharm, PhD; and T. Sivakumar, MPharm, PhD

Purpose: Our purpose in this study was to compare the efficacy, tolerability, and safety of a multicomponent antiinflammatory preparation containing glucosamine hydrochloride (g hydrochloride) or plain glucosamine sulfate (g sulfate) with that of a nonsteroidal antiinflammatory drug (NSAID), aceclofenac, in the treatment of knee osteoarthritis.

Methods: Forty-five patients with active osteoarthritis of the knee joint were randomized to receive g hydrochloride, g sulfate, or aceclofenac for 12 weeks. The patients were evaluated by the Western Ontario and McMaster Universities (WOMAC) osteoarthritis-index scale, and bone-resorption assessment was
done by measuring levels of pyridinoline and deoxypyridinoline from morning first-void urine samples of patients at baseline and at every 4-week interval until 4 weeks after drug discontinuation.
Antero-posterior radiographs of affected knees were taken at baseline and after 12 weeks of therapy.

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This entry was posted in Glucosamine, Innovision Health Media, Integrative Medicine Clinicians Journal, Knee Pain, Osteoarthritis and tagged , . Bookmark the permalink. Follow any comments here with the RSS feed for this post.
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