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Daxitrol: A Novel Approach for Controlling Cravings

David Marc, B.Sc. , & Kelly Olson Ph.D .

Abstract
Cravings are defined as an intense drive or desire directed towards food, drugs, gambling, and other stimuli. The pleasure/reward and motivational pathways associated with cravings involve multiple neurotransmitters including dopamine, glutamate, serotonin, acetylcholine, and various peptides. These neurotransmitters also serve as therapeutic targets to modulate the pleasure/reward pathway. Daxitrol is a novel product that contains L-3,4-dihydroxyphenylalanine (L-DOPA), epigallocatechin gallate (EGCG), N-acetylcysteine (NAC), 5-hydroxytryptophan (5- HTP), L-phenylalanine, forskolin, and huperzine A (HupA) to manage cravings and enhance self-control. This overview will present the neurological pathways that underlie cravings and propose the use of Daxitrol to ameliorate cravings. Information will be provided that discusses how Daxitrol targets dopamine, glutamate, serotonin, acetylcholine, and the peptide cholecystokinin (CCK) to help decrease cravings and impulsivity.

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