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Compounded Dispersion Formulations, Part I

Amir H. Shojael, Pharm D, PhD

When one considers that most compounded prescriptions are forms of dispersed systems, it becomes imperative to grasp a thorough understanding of the theory and technology behind pharmaceutical dispersions. This [article] describes dispersed systems and the effects of improper compounding of dispersions on bioavailability and stability of the products. Dispersions are mixtures of two or more ingredients that are not mutually miscible and capable of forming homogeneous solutions. In a given dispersion, the collection of particles that are evenly distributed throughout a continuous or dispersion medium is referred to as the dispersed phase. Pharmaceutical dispersions are classified on the basis of their state of matter or particle size (see Tables 1 and 2). The more relevant classification is based on the mean particle diameter of the dispersed material, classifying dispersed systems into molecular, colloidal, and coarse dispersions. As molecular dispersions are not within the scope of this [article], the following discussion will be focused on colloidal and coarse dispersions.

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