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Clinical Effects Of A Proprietary Combination Isoflavone Nutritional Supplement In Menopausal Women: A Pilot Trial

Daniel Lukaczer, ND, Gary Darland, PhD, Matthew Tripp, PhD, DeAnn Liska, PhD, Robert H. Lerman, MD, PhD, Barbara Schiltz, MS, RN, Jeffrey S. Bland, PhD

Women often experience climacteric symp- toms as they reach menopause. These symptoms can vary in intensity and fre- quency, but most often include hot flushes, night sweats, and vaginal dryness.
Estimates of the number of menopausal women who experience these symptoms vary widely, with some studies suggesting that 75% to 85% of women in Western countries report menopausal complaints, while rates in Asian countries are as low as 15%.1,2

Hormone replacement therapy (HRT) is recognized as the most effective treatment for the relief of short-term symptoms of menopause. Recent findings, however, suggest that HRT may increase the long-term risks for breast cancer, thromboem- bolism, and cardiovascular disease (CVD).3 Additionally, many women taking HRT experience unpleasant side effects, such as vaginal bleeding, breast tenderness, and bloating. It is therefore not surprising that the overall compliance using this therapy is <20%.4,5 Clearly, the early promise of HRT as a panacea for menopausal women has not been realized.

Plants containing isoflavones have traditionally been used in Asian countries for the relief of climacteric symptoms. Isoflavones are found in soy, kudzu, and red clover, and have been shown to bind to estrogen receptors and exert weak estro- genic as well as antiestrogenic effects. Because of their ability to both positively and negatively influence estrogen activities,isoflavones have been called nature’s selective estrogen receptor modulators(SERMs).

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This entry was posted in Articles, Bioidentical Hormones, Integrative Medicine Clinicians Journal, Menopause, Nutrition/Vitamins/Minerals/Dietary Supplements, Nutritional Medicine, Supplement Science. Bookmark the permalink. Follow any comments here with the RSS feed for this post.
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