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Cancer: Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool

Research article by Soon Ling Poon, See-Tong Pang et al.

Genomic sequencing experts at Johns Hopkins partnered with pharmacologists at Stony Brook University to reveal a striking mutational signature of upper urinary tract cancers caused by aristolochic acid, a plant compound contained in herbal remedies used for thousands of years to treat a variety of ailments such as arthritis, gout and inflammation.

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