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Avipaxin and Modulation of the Immune System

David Marc, M.B. , Deanna Fall, B.A. & Kelly Olson Ph.D .

Avipaxin is a dietary supplement that contains huperzine A (HupA), L-alpha-glycerylphosphorylcholine (α-GPC), and acetyl-L-carnitine to support acetylcholine levels and function. HupA is a powerful central nervous system (CNS) acetylcholinesterase (AChE) inhibitor and has been proposed as a natural agent to promote healthy immune system function. α-GPC is a natural choline compound, and acetyl-L-carnitine acts as an acetyl donor to support the synthesis of acetylcholine. The immunomodulatory effects of Avipaxin may be mediated by support of acetylcholine levels and activity. Avipaxin appears to regulate systemic immune activation by supporting the cholinergic immune-regulating pathway to ultimately reestablish homeostasis following an immune challenge. The following overview will present research on the features of Avipaxin and the functional significance of muscarinic receptors, nicotinic receptors, the vagus nerve, and the splenic nerve. The mechanism for which Avipaxin promotes a healthy immune system is reviewed with focus on how a centrally acting agent can modulate peripheral immune system activity.

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