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Antihyperglycemic Effects of Propolis Mixed With Mulberry Leaf Extract On Patients with Type 2 Diabetes

Kohji Murata, MD, Kazuhisa Yatsunami, PhD, Eiichi Fukuda, Satoshi Onodera, PhD,
Osamu Mizukami, MD, PhD, Gen Hoshino, MD, Tsutomu Kamei, MD, PhD

Mulberry leaf (Morus alba L.), a traditional Chinese herb, has been used to treat diabetes mellitus and to alleviate thirst.1 From mulberry leaf extract, 6 N-containing sugars, such as N-methyl 1-deoxynojirimycin, 2-O-a-D-galactopyranosyl- DNJ, and fagomine, have recently been identified and may have antihyperglycemic effects.2,3 Bees make propolis by collecting balsam or nectar from various trees and plants. They then mix this with saliva and various active flavonols such as quercetin,4 which also has demonstrated antihyperglycemic effects.5 Hot water extract from mulberry leaves was mixed with an ethanol extract from propolis named Quapolis. We investigated the effects of propolis mixed with mulberry leaf extract on type 2 diabetic patients. All patients had blood-glucose control problems for which conventional treatments such as sulfonylureas and/or a-glucosidase inhibitors were ineffective.

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